|
KMID : 0191120200350370306
|
|
Journal of Korean Medical Science
2020 Volume.35 No. 37 p.306 ~ p.306
|
|
|
A Meta-Analysis on the Performance of Cystatin C- versus Creatinine-based eGFR Equations in Predicting Vancomycin Clearance
|
|
Tahir Nor Asyikin Mohd
Saffian Shamin Mohd
Islahudin Farida Hanim
Gafor Abdul
Makmor-Bakry Mohd
|
|
|
Abstract
|
|
|
Background: The objective of this study was to compare the performance of cystatin C- and creatinine-based estimated glomerular filtration rate (eGFR) equations in predicting the clearance of vancomycin.
Methods: MEDLINE and Embase databases were searched from inception up to September 2019 to identify all studies that compared the predictive performance of cystatin C- and/or creatinine-based eGFR in predicting the clearance of vancomycin. The prediction errors (PEs) (the value of eGFR equations minus vancomycin clearance) were quantified for each equation and were pooled using a random-effects model. The root mean squared errors were also quantified to provide a metric for imprecision.
Results: This meta-analysis included evaluations of seven different cystatin C- and creatinine-based eGFR equations in total from 26 studies and 1,234 patients. The mean PE (MPE) for cystatin C-based eGFR was 4.378 mL min?1 (95% confidence interval [CI], ?29.425, 38.181), while the creatinine-based eGFR provided an MPE of 27.617 mL min?1 (95% CI, 8.675, 46.560) in predicting clearance of vancomycin. This indicates the presence of unbiased results in vancomycin clearance prediction by the cystatin C-based eGFR equations. Meanwhile, creatinine-based eGFR equations demonstrated a statistically significant positive bias in vancomycin clearance prediction.
Conclusion: Cystatin C-based eGFR equations are better than creatinine-based eGFR equations in predicting the clearance of vancomycin. This suggests that utilising cystatin C-based eGFR equations could result in better accuracy and precision to predict vancomycin pharmacokinetic parameters.
|
|
|
KEYWORD
|
|
|
Cystatin C, Creatinine, Vancomycin, Clearance, eGFR
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|